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GENUINE SOLUTIONS FOR THE DISEASES OF CIVILIZATION







Eight Reasons You Canít Lose Fat

SEPTEMBER 20, 2017
Inability to lose weight is the most common reason people see me. Itís often a combination of small things that they are unaware of that is keeping the spare tire inflated around the waist. Iíve listed the eight most common reasons you canít lose fat that are seen in my office.
You Eat Too Many Carbohydrates

About 85% of the people that walk through my office doors have some degree of insulin resistance. This means that they produce 2-20 times the normal amount of insulin in response to ANY form of starch or carbohydrate. Insulin is the hormone responsible for letting glucose into the cell to be used as fuel. More importantly, it is the hormone responsible for dampering glucose production in the liver and, it is the primary hormone responsible for pushing triglycerides into the fat cells (essentially, the master hormone for making you FAT). The more insulin you make the more fat you store. Insulin resistance, the inability for insulin to signal glucose dampering at the liver receptors, is the first stage that starts 15-20 years before you become a diabetic.
In order to lose fat, you have to decrease the insulin to a basal level. If you donít the fat enters the fat cell faster than it exits and the fat cells get bigger. This is RULE number one to weight loss. You gotta turn down the high insulin surge that 85% of us are really good at producing. If you donít do this, it is almost impossible for many of us to lose weight.
For at least 1/3rd of the people I see, this cannot be accomplished unless TOTAL CARBOHYDRATES are decreased to less than 20 grams per day. Yes, you read that correctly . . . Less that 20 grams per day.

  • Your banana contains 30 grams of carbohydrate
  • Your yogurt has up to 60 grams of carbohydrate
  • That oatmeal you thought was good for you has up to 200 grams of carbohydrate
  • The half and half you put in your coffee is half lactose (sugar from milk), 10 grams per cup.

You Eat Too Much Protein

Yes, protein can cause weight gain. There is always a body builder that sends me a nasty message after I say this, but it is true. (Iíll keep an eye on my e-mail).

Five of the ten essential amino acids stimulate an insulin response. Remember why carbohydrates cause weight gain . . . ? (I will give you a hint . . . INSULIN).
Certain amino acids that make up proteins can do the same thing. Arginine, Lycine, Phenylalanine, Leucine & Tyrosine, in that order, stimulate insulin (1). We need protein to stay healthy, but too much of these amino acids in someone who is insulin resistant will inhibit weight loss and stimulate fat gain.
So, what foods contain these in the highest amounts? Sea lion liver (I know, this wonít go over very well with the polar bears), soy protein isolate, crab, shrimp, sesame flour, turkey breast, pork loin (itís the leanest cut of pork Ė No. BACON is fine), chicken, pumpkin seeds, soybeans, peanuts, spirulina (blue green alge that is found in the sea). Yes, I get it. Weíve been told these were the healthy foods for the last 50 years. But, think about it, when did we start gaining weight as a country? 50 years ago.
Too much chicken, shrimp, crab and soy foods will inhibit weight loss in those with insulin resistance. So, consider whether it should be chicken you add to your salad. Consider, instead, bacon or beef as a wonderfully tasty substitute.
How much protein do you need? My formula for calculating your individual amount is here in my blog Calculating Protein Needs.
You Donít Eat Enough Fat


To successfully lose fat on a ketogenic diet, 60-70% of your caloric intake should come from fat. Yes. You read that correctly.
If we limit carbohydrates (which is currently 80% of the bodyís fuel on the standard America plate), and moderate excessive protein which also halts weight loss, you have to replace the fuel. That fuel replacement should come from fat. Increasing fat will improve the sensation of fullness, provide all the fat soluble vitamins, and actually makes food taste good again.
As long as you are lowering the insulin to basal levels, you can actually eat all the fat for which you are hungry. Add bacon, butter, coconut oil, avocado, hard cheese, and oh, did I say bacon?
But Dr. Nally, what about all that saturated fat?
The saturated fat is only a problem with vascular disease, cholesterol and heart disease when the insulin level is also high at the same time. Itís the high insulin in the presence of large amounts of fat that drives the risk for atherosclerosis (vascular and heart disease). Instead of cutting out the fat, weíre cutting out the insulin.
How much fat should you be eating? Shoot for 60-70% of your calories from fat. If your fat grams are slightly higher than your protein grams, youíre there. Listen to your body and eat fat until youíre full. Thatís how most of my patients gauge their need and suppress hunger.
Youíre Drinking Tea

I know, I know. Tea is a national pass time in Europe. And, it is deeply embedded in the culture of many other countries. Iím probably not winning any friends across the pond by saying this, and it may bring back memories of the Boston Tea Party. However, the problem is that leaf based teas stimulate a rise in insulin (not taxes). I have had many patients hit a weight loss plateau because of the use of tea, specifically black tea, oolong tea, and green tea (2,3,4).
Yes, I am well aware of the tremendous benefits of the epigallocatechin gallate (ECGC) found in green tea. ECGC, which can be isolated as an extract, improves insulin resistance and improves GLP-1 signaling. ECGC has, also, been show to improve triglycerides (5). For this reason, it is one of the components in the KetoEssentials Multi-Vitamin I developed a few years ago and recommend to all my patients.
It appears, however, that the theaflavin within the leaf of the tea may be playing the offending role in the insulin spike seen with their use (6).
You Donít Get Enough Sleep

Lack of sleep has been implicated in difficulty with weight loss and weight gain (7). Lack of sleep places the body into a state of chronic stress. This elevates cortisol, lowers testosterone, increases insulin (thereís that insulin problem, again) and increases the other inflammatory hormones. This perfect storm of stress, driven by lack of restful sleep, plays a big role in fat loss.
My average patient needs at a minimum of 6-7 hours of restful sleep to maintain and lose weight.
This is where untreated sleep disorders like sleep apnea play a big role. If you have sleep apnea, get it treated. What else can you do to help improve sleep?

  • Remove the computer, iPad and cell phones from the room.
  • Lower the room temperature. Men sleep better around 68-70 degrees F and women sleep better when the temperature is <70 degrees F.
  • Close the blinds or shades to add or darken the room.
  • Donít study or watch TV in the same room you sleep in. Your body gets used to doing certain activities in certain rooms of the house. The bedroom should be reserved for sleep.
  • Go to bed at the same time
  • Get up at the same time.

It may take your body and bodyís biorhythm 3-4 weeks to adjust to changes you make around sleep habits. Be patient with yourself.
Youíre Married to Stress

Just as lack of sleep is stressful, other forms of chronic stress also raise cortisol, insulin and the inflammatory hormones. Chronic stress also lowers testosterone. It, also, has the potential to lower neurosignaling hormones in the brain like serotonin and dopamine, putting you at greater risk for depression and anxiety.
Other forms of chronic stress can occur from poor relationships, chronic pain, stressful employment, unfulfilled expectations, chronic illness and all forms of abuse. If any of these are playing a role in your life, you need to address them, and address them now.
As a physician, my job is stressful. Dealing with life and death issues with multiple people through the day, six or seven days a week, takes itís toll. Iíve found that weight lifting, horseback riding, and taking care of my animals are my outlets. Find something physical, that takes you outside in the elements and forces you to break a sweat for 15-20 minutes is the key.
Our bodies have a ďfight or flight system.Ē 100 years ago, the stress was fighting or running from the bear that squared off with you when you happened upon him in the woods. Cortisol, adrenaline, epinephrine, insulin, glucose, and inflammatory hormones pour into the blood stream. The heart beats faster, blood flows rapidly to the muscles, sensory awareness is heightened in the brain and increased oxygen flows to the lungs. This lets you fight the bear or run from the bear.
But, you canít fight or run from your cynical boss. You canít fight or run from oppressive finances, the person that cuts you off on your one hour commute in traffic, or your coworker who keeps pestering you. However, your body still releases adrenaline, cortisol, epinephrine, insulin and a number of inflammatory hormones prepping you to fight or run. If you donít burn these hormones off, they halt weight loss, and actually can cause weight gain, increase anxiety and over time disrupt sleep.
So find your favorite way of physically relieving stress, and do it 2-3 times per week. (No, gentlemen, sex doesnít count).
You Have An MTHFR Deficiency

In the last few years, weíve been able to identify a number of genetic deficiencies that play a role in weight gain. One of those is an methyl-tetrahydrofolate enzyme deficiency (MTHFR deficiency for short). This is a genetic deficiency in the enzyme that converts adds a methyl ion to the folic acid in the cells of your body.
This is important, because if you canít methylate folic acid inside the cell, youíll have difficulty using vitamin B12 and B6 very efficiently to form methionine (a key amino acid in blood vessel and nerve function). There are two genes that encode for the enzyme that does the methylation of folic acid. Deficiency in one or both of these can lead to problems.
In severe cases, it causes homocysteine to build up to unsafe levels in the blood and slow the formation of methionine. It is associated with B12 deficiency, weight gain, fatigue, migraines, depression, anxiety, neuro-developmental disorders like autism, pregnancy loss, blood clots and neuropathy in pre-diabetic and diabetic patients (8, 9, 10).
Giving extra vitamin B12, B6 and folic acid (vitamin B9) doesnít appear to help. Clinical evidence is pointing to the pre-methylated form of the folic acid. Finding this pre-methylated form has been difficult and notably expensive for patients. I found this deficiency to be so prevalent in my office, I added methylated folic acid to the KetoEssentials Multivitamin.
You Give ďCouch PotatoĒ A New Name



We have become a very sedentary people. We have engineered physical activity out of our lives. Remote controls, elevators, escalators, people movers, and automation have made our lives physically easier.
The average office worker burns 300 kcal per day sitting at a desk on a computer. The average farm worker burns 2600 kcal per day. Thatís the equivalent of running a marathon every day.
Physical activity doesnít necessarily cause weight loss. However, physical activity changes the hormones of the body including increasing a hormone called atrial naturitic peptide (ANP). ANP opens the fat cell, and lets more fat out (11).
When physical activity is paired with the correct diet, the weight come off. This is where exogenous ketones may play a role. The increased presence of ketones in the blood increases the release of ANP helping to activate triglyceride release from the fat cell.
Donít get me wrong, many of my patients can lose weight with just dietary carbohydrate restriction alone, however, if youíve hit a stall, you may need to look at your physical activity levels and the addition of exogenous ketones.
Kickstart Ketosis over the Plateau

Is your fat loss on a plateau? Knowing that these challenges plague people over the coming holidays, and, seeing people get hung up on these issues, Iíve created the Keto Kickstart program for the month of October. This package provides 30 days of ketogenic essentials including vitamins, exogenous ketones and private interaction with me through the month of October to help you get over the plateau and breeze through the holidays.
Click on Kickstart to find out the details, join me next month and let me help you bridge the weight loss chasm!
References:

  1. Floyd J et al., Stimulation of Insulin Secretion by Amino Acids, Journal of Clinical Investigation. 1966. 45(9).
  2. Bryans JA et al., Effect of black tea on post-prandial glucose and insulin. Journal Am Coll Nutrition 2007, 25(5): 471-7.
  3. Store KS & Baer DJ. Tea consumption may improve biomarkers of insulin sensitivity and risk factors for diabetes. The Journal of Nutrition. Aug 2008, 138(8): 1584S-1588S.
  4. Hosoda K et al., Anti-hyperglycemic effect of oolong tea on type II diabetes. Diabetes Care. Jun 2003. 26(6): 1714-1718.
  5. Chia-Yu Liu,Chien-Jung Huang, Lin-Huang Huang, I-Ju Chen, Jung-Peng Chiu, Chung-Hua Hsu. Effects of Green Tea Extract on Insulin Resistance and Glucagon-Like Peptide 1 in Patients with Type 2 Diabetes and Lipid Abnormalities: A Randomized, Double-Blinded, and Placebo-Controlled Trial. PLOS one(online). March 10, 2014.
  6. Cameron, Amy R.; Anton, Siobhan; Melville, Laura; Houston, Nicola P.; Dayal, Saurabh; McDougall, Gordon J.; Stewart, Derek; Rena, Graham (2008). ďBlack tea polyphenols mimic insulin/insulin-like growth factor-1 signalling to the longevity factor FOXO1aĒ. Aging Cell. 7(1): 69Ė77.
  7. Beccuti, Guglielmo, and Silvana Pannain. ďSleep and Obesity.Ē Current opinion in clinical nutrition and metabolic care 14.4 (2011): 402Ė412. PMC. Web. 18 Sept. 2017.
  8. Divyakolu S, Tejaswini Y, Thomas W, Thumoju S, et al. (2013) Evaluation of C677T Polymorphism of the Methylenetetrahydrofolate Reductase (MTHFR) Gene in various Neurological Disorders. J Neurol Disord 2:142. doi: 10.4172/2329-6895.1000142
  9. Gilbody, S., Lewis, S. & Lightfoot, T. (2007). Methylenetetrahydrofolate reductase (MTHFR) genetic polymorphisms and psychiatric disorders: A HuGE review. American Journal of Epidemiology, 165(1), 1-13.
  10. Menon, S., Lea, R., Roy, B., Hanna, M., Wee, S., Haupt, L., & Ö Griffiths, L. (2012). Genotypes of the MTHFR C677T and MTRR A66G genes act independently to reduce migraine disability in response to vitamin supplementation. Pharmacogenetics And Genomics, 22(10), 741-749.
  11. Lafontan M et al., Control of lipolysis by natriuretic peptides and cyclic GMP. Trends in Endocrinology and Metabolism. 19(4): 130-137.

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